This course provides an in-depth examination of the fundamental biological processes that drive aging at the molecular, cellular, and systems levels. Students will explore the major hallmarks of aging, including genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. The course integrates mechanistic insights with their relevance to age-associated diseases such as cancer, neurodegeneration, and metabolic disorders. Emphasis is placed on linking molecular pathways to physiological decline and identifying potential therapeutic targets for healthspan extension. Through lectures, case-based discussions, and critical analysis of current literature, students will develop the ability to interpret emerging research in geroscience and evaluate strategies aimed at modulating aging processes for translational and clinical applications.
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